A method for preparing a cyclopeptide and a cyclopeptide preparing by the method are disclosed. The method comprises the following steps: (A) providing compounds represented by the following formulas (I-1) and (I-2),
(I-1) (I-2)
wherein G, Ra, Rb, Rc, Rd, and Re are defined in the specification; (B) performing a reaction between the compound of formulas (I-1) and (I-2), to obtain a compound represented by the following formula (I-3),
(I-3); and (C) performing a cyclization reaction of the compound of formula (I-3) with a catalyst of formula (II) and deprotection, to obtain a compound represented by the following formula (III),
(III) M(O)mL1yL2z (II)
wherein, G’, Q, M, L1, L2, m, y, and z are defined in the specification. |