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專利授權區

專利授權區
專利名稱(中)	口服藥物傳遞系統及其製備方法
專利名稱(英)	ORAL DRUG DELIVERY SYSTEM AND METHOD FOR FABRICATING THEREOF
專利家族	美國：US-2023-0157956-A1(公開號)
專利權人
發明人	宋信文,繆養寶,陳冠宏
技術領域	生化醫藥

專利摘要(中)
本發明提供一種口服藥物傳遞系統，其包含仿生礦化載體以及酵母膠囊。前述仿生礦化載體包含金屬有機骨架和生物大分子，金屬有機骨架具有一內部空間，生物大分子被包覆於金屬有機骨架之內部空間中。而前述酵母膠囊裝載仿生礦化載體。藉此，本發明之口服藥物傳遞系統可保護其中所包覆的生物大分子抵抗胃腸道中的pH值變化和蛋白酶，使所包覆的生物大分子維持活性，並可靶向腸道的微皺褶細胞，使本發明之口服藥物傳遞系統以膜吞噬模式有效地跨上皮運輸以突破黏膜屏障。

專利摘要(中)

本發明提供一種口服藥物傳遞系統，其包含仿生礦化載體以及酵母膠囊。前述仿生礦化載體包含金屬有機骨架和生物大分子，金屬有機骨架具有一內部空間，生物大分子被包覆於金屬有機骨架之內部空間中。而前述酵母膠囊裝載仿生礦化載體。藉此，本發明之口服藥物傳遞系統可保護其中所包覆的生物大分子抵抗胃腸道中的pH值變化和蛋白酶，使所包覆的生物大分子維持活性，並可靶向腸道的微皺褶細胞，使本發明之口服藥物傳遞系統以膜吞噬模式有效地跨上皮運輸以突破黏膜屏障。

專利摘要(英)
A method for fabricating an oral drug delivery system includes steps as follows. A mixture is provided, which includes an organic ligand, a metal ion, a biological macromolecule and water. A coating step is performed for forming a biomimetic mineralized carrier encapsulated the biological macromolecule having a surface with the positive charge. A first solution including the biomimetic mineralized carrier is provided. A second solution including a yeast capsule is provided, wherein the yeast capsule has a surface with the negative charge. A loading step is performing, wherein the first solution is mixed with the second solution and then shaken for a shaking time, and the biomimetic mineralized carrier is loaded into the yeast capsule by an electrostatic force to form the oral drug delivery system.

專利摘要(英)

A method for fabricating an oral drug delivery system includes steps as follows. A mixture is provided, which includes an organic ligand, a metal ion, a biological macromolecule and water. A coating step is performed for forming a biomimetic mineralized carrier encapsulated the biological macromolecule having a surface with the positive charge. A first solution including the biomimetic mineralized carrier is provided. A second solution including a yeast capsule is provided, wherein the yeast capsule has a surface with the negative charge. A loading step is performing, wherein the first solution is mixed with the second solution and then shaken for a shaking time, and the biomimetic mineralized carrier is loaded into the yeast capsule by an electrostatic force to form the oral drug delivery system.

聯絡資訊
承辦人姓名	李佳玲
承辦人電話	03-5715131 #62300
承辦人Email	cl.lee@mx.nthu.edu.tw