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專利授權區


專利授權區
專利名稱(中) 巨分子藥物之製備及給藥方法
專利名稱(英) METHOD FOR ORAL ADMINISTRATION OF AN ACTIVE INGREDIENT
專利家族 美國:9,216,207
專利權人 國立清華大學 100%
發明人 宋信文
技術領域 生化醫藥
專利摘要(中)
A method for oral administration of an active ingredient to a subject is provided whereby a plurality of bubbles containing the active ingredient t are formed in a small intestinal of the subject. The method includes administering orally to the subject an effective amount of the above-mentioned pharmaceutical composition. The pharmaceutical composition includes a drug layer and an enteric coating layer. The drug layer comprises an active ingredient, a surfactant, an acidic component and an effervescent ingredient. The active ingredient comprises a nucleic acid, a peptide or a protein. When the acidic component of the drug layer is dissolved in the small intestinal to react with the effervescent ingredient for generating carbon dioxide and the plurality of bubbles containing the active ingredient, and the active ingredient is embedded in a gap formed between an inner layer and an outer layer of an double-layer structure formed by the surfactant.
聯絡資訊
承辦人姓名 鍾弦靜
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