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專利授權區

專利授權區
專利名稱(中)	口服藥物傳遞系統及其製備方法
專利名稱(英)	ORAL DRUG DELIVERY SYSTEM AND METHOD FOR FABRICATING THEREOF
專利家族	中華民國：I727411 美國：US-2021-0059945-A1(公開號)
專利權人	國立清華大學 100%
發明人	宋信文,繆養寶,陳冠宏
技術領域	生化醫藥

專利摘要(英)
The invention relates to an oral drug delivery system including a biomimetic mineralized carrier and a yeast capsule. The biomimetic mineralized carrier includes a metal-organic framework and a biological macromolecule, in which the metal-organic framework has an internal space, and the biological macromolecule is coated in the internal space of the metal-organic framework. The yeast capsule is loaded with the biomimetic mineralized carrier. Therefore, the oral drug delivery system can protect the biological macromolecule coated therein against pH changes and proteases in the gastrointestinal tract, and maintain activity of the biological macromolecule coated therein. In addition, the oral drug delivery system can target microfold cells of the intestinal tract, allowing the oral drug delivery system of the present invention to effectively transport across the intestinal epithelium in a membrane phagocytic mode to break through the mucosal barrier.

專利摘要(英)

The invention relates to an oral drug delivery system including a biomimetic mineralized carrier and a yeast capsule. The biomimetic mineralized carrier includes a metal-organic framework and a biological macromolecule, in which the metal-organic framework has an internal space, and the biological macromolecule is coated in the internal space of the metal-organic framework. The yeast capsule is loaded with the biomimetic mineralized carrier. Therefore, the oral drug delivery system can protect the biological macromolecule coated therein against pH changes and proteases in the gastrointestinal tract, and maintain activity of the biological macromolecule coated therein. In addition, the oral drug delivery system can target microfold cells of the intestinal tract, allowing the oral drug delivery system of the present invention to effectively transport across the intestinal epithelium in a membrane phagocytic mode to break through the mucosal barrier.

聯絡資訊
承辦人姓名	李佳玲
承辦人電話	03-5715131 #62300
承辦人Email	cl.lee@mx.nthu.edu.tw