專利授權區
國立清華大學國際產學營運總中心 > 智財技轉組 > 專利授權區
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專利授權區
 專利授權區 |
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| 專利名稱(中) | 以ＣＸＣ趨化因子受體４爲標靶之奈米粒子用於製備治療肝癌與抑制肝癌轉移之醫藥組成物的用途 |
| 專利名稱(英) | Method for treatment of liver cancer and inhibition of metastasis with CXC-chemokine-receptor 4-targeted nanoparticle |
| 專利家族 |
中華民國：I556830 美國：9,415,011 |
| 專利權人 | 國立清華大學 100% |
| 發明人 | 高棟禹,劉家瑜,陳韻晶 |
| 技術領域 | 材料化工,生化醫藥 |
 專利摘要(中) |
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| Provided is a method for treatment of liver cancer and inhibition of metastasis with CXCR4-targeted nanoparticle. A CXCR4 antagonist is used as a targeting molecule to modify a lipid carrier for the formation of nanoparticle carrying an anti-angiogenesis drug or an anti-angiogenic nucleotide. Such nanoparticle can enhance the accumulation and uptake of the drug and nucleotide in liver cancer cells as well as sensitize the liver cancer cells to treatment of said drug and nucleotide, providing a synergistic suppression of angiogenesis and tumor progression. Furthermore, the CXCR4-targeted nanoparticle can effectively inhibit metastasis of liver cancer. The pharmaceutical composition is an injectable composition; hence, is suitable for clinical application for the treatment of liver cancer. |
 聯絡資訊 |
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| 承辦人姓名 | 劉千綺 |
| 承辦人電話 | 03-571-5131 #31181 |
| 承辦人Email | chienchi@mx.nthu.edu.tw |
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