專利授權區國立清華大學國際產學營運總中心 Operations Center for Industry Collaboration

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專利授權區

專利授權區
專利名稱(中)	可同時口服傳遞疏水性小分子藥物和親水性小分子藥物的醫藥組合物
專利名稱(英)	PHARMACEUTICAL COMPOSITION FOR ORAL DELIVERY OF HYDROPHOBIC SMALL MOLECULE DRUG AND HYDROPHILIC SMALL MOLECULE DRUG CONCURRENTLY
專利家族	中華民國：I739450
專利權人	國立清華大學 100%
發明人	林柏諺,宋信文
技術領域	生化醫藥

專利摘要(英)
The invention relates to a pharmaceutical composition including an enteric layer and a drug layer. The drug layer includes a therapeutically effective amount of hydrophobic small molecule drugs, a therapeutically effective amount of hydrophilic small molecule drugs, a lipophilic solvent, an acidic compound and an effervescent ingredient. When the pharmaceutical composition enters the intestinal tract through oral administration, carbon dioxide bubbles are generated. The disturbance caused by the expansion and rupture of the carbon dioxide bubbles causes the pharmaceutical composition to self-emulsify to form lipid oil drops with the hydrophobic small molecule drugs, and the hydrophilic small molecule drugs are dissolved in the intestinal fluid. Therefore, the pharmaceutical composition does not need to use a toxic carrier, and can deliver the hydrophobic small molecule drug and the hydrophilic small molecule drug concurrently through oral administration, and can increase the solubility of the drug to improve oral bioavailability.

專利摘要(英)

The invention relates to a pharmaceutical composition including an enteric layer and a drug layer. The drug layer includes a therapeutically effective amount of hydrophobic small molecule drugs, a therapeutically effective amount of hydrophilic small molecule drugs, a lipophilic solvent, an acidic compound and an effervescent ingredient. When the pharmaceutical composition enters the intestinal tract through oral administration, carbon dioxide bubbles are generated. The disturbance caused by the expansion and rupture of the carbon dioxide bubbles causes the pharmaceutical composition to self-emulsify to form lipid oil drops with the hydrophobic small molecule drugs, and the hydrophilic small molecule drugs are dissolved in the intestinal fluid. Therefore, the pharmaceutical composition does not need to use a toxic carrier, and can deliver the hydrophobic small molecule drug and the hydrophilic small molecule drug concurrently through oral administration, and can increase the solubility of the drug to improve oral bioavailability.

聯絡資訊
承辦人姓名	劉千綺
承辦人電話	03-571-5131 #31181
承辦人Email	chienchi@mx.nthu.edu.tw