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專利授權區

專利授權區
專利名稱(中)	口服醫藥組合物、其製備方法及治療癌症之套組
專利名稱(英)	ORAL PHARMACEUTICAL COMPOSITION, METHOD FOR FABRICATING THE SAME AND KIT FOR TREATING CANCER
專利家族	中華民國：202423396(公開號) 美國：US-2024-0197911-A1(公開號)
專利權人	國立清華大學 100.00%
發明人	宋信文,陳冠宏,黃敦域,阮黃素然,林鈺容,余祐慈
技術領域	材料化工,生化醫藥

專利摘要(中)
本發明提供一種口服醫藥組合物，其包含金屬錯合物以及外層。所述金屬錯合物係於由有機物配位鍵結至金屬離子而形成，其中所述有機物為芳香族化合物且包含至少二個氧原子。所述外層包含β-葡聚醣，β-葡聚醣分散於金屬錯合物外且配位鍵結至金屬錯合物構成所述外層。藉此，前述口服醫藥組合物可在極端的腸道環境中保持穩定，且能標靶微皺摺細胞經淋巴系統吸收進入體內，並被免疫細胞吞噬後攜帶至病灶處。

專利摘要(中)

本發明提供一種口服醫藥組合物，其包含金屬錯合物以及外層。所述金屬錯合物係於由有機物配位鍵結至金屬離子而形成，其中所述有機物為芳香族化合物且包含至少二個氧原子。所述外層包含β-葡聚醣，β-葡聚醣分散於金屬錯合物外且配位鍵結至金屬錯合物構成所述外層。藉此，前述口服醫藥組合物可在極端的腸道環境中保持穩定，且能標靶微皺摺細胞經淋巴系統吸收進入體內，並被免疫細胞吞噬後攜帶至病灶處。

專利摘要(英)
The invention relates to an oral pharmaceutical composition including a metal complex and an outer layer. The metal complex is formed by coordinate bonding of an organic to metal ions, wherein the organic is an aromatic compound and includes at least two oxygen atoms. The outer layer includes a β-glucan, and the β-glucan is dispersed outside the metal complex and is coordinately bonded to the metal complex to form the outer layer. Therefore, the oral pharmaceutical composition can be kept stable in the extreme intestinal environment, and can be absorbed into the body through the lymphatic system, and can be phagocytosed by immune cells and carried to the lesion.

專利摘要(英)

The invention relates to an oral pharmaceutical composition including a metal complex and an outer layer. The metal complex is formed by coordinate bonding of an organic to metal ions, wherein the organic is an aromatic compound and includes at least two oxygen atoms. The outer layer includes a β-glucan, and the β-glucan is dispersed outside the metal complex and is coordinately bonded to the metal complex to form the outer layer. Therefore, the oral pharmaceutical composition can be kept stable in the extreme intestinal environment, and can be absorbed into the body through the lymphatic system, and can be phagocytosed by immune cells and carried to the lesion.

聯絡資訊
承辦人姓名	李馥如